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Alison K. Meadows, M.D.
Dr. Alison Knauth Meadows is a pediatric cardiologist with expertise
in the care of Adults with Congenital Heart Disease (ACHD). She has a
particular interest in the care of the young adult with complex congenital
heart disease and has developed a Transition Program to guide their transfer
from pediatric- to adult-centered care. Dr. Meadows additionally has an
expertise in the performance and interpretation of cardiac Magnetic Resonance
Imaging (MRI) in adults and children with congenital and acquired heart
disease.
Dr. Meadows’ research activities draw upon doctoral studies in
bioengineering and MRI physics. She uses existing and develops novel MRI
technologies to address clinical questions facing children and adults
with congenital heart disease. Examples of past and current research activities
include:
- Development of microscopic imaging techniques to investigate cardiovascular
embryology.
- Integration of interventional catheterization and cardiac MRI.
- Use of MRI to predict outcomes in a variety of congenital heart defects
such as tetralogy of Fallot.
- Development of MRI blood flow techniques to investigate vascular physiology
and compliance.
- Use of MRI myocardial tagging to evaluate ventriculo-arterial coupling.
Dr. Meadows' current research activities are primarily aimed at developing
and validating a computational model that will permit noninvasive characterization
of dynamic afterload and its impact on myocardial performance in healthy
and disease states, and to predict response to intervention (catheter-based,
surgical, or medical). Such a tool holds particular relevance for the
emerging population of adults with complex congenital heart disease (ACHD),
in whom ventriculo-arterial coupling remains poorly understood.
 Only
selected publications are listed below. Click on the icon to the left
for a complete listing of publications available on Pub Med.
- Hope MD, Meadows AK, Hope TA, Ordovas K, Saloner
D, Reddy GP, Alley MT, Higgins CB. Evaluation of Bicuspid Aortic Valve
and Aortic Coarctation with 4D Flow MR Imaging. Circulation 2008; 117(21),
2818-19.
- Knauth A, Verstappen A, Reiss J, Webb GD, Transition
and Transfer from Pediatric to Adult Care of the Young Adult with Complex
Congenital Heart Disease, Cardiology Clinics 2006; 24(4):619-29.
- Knauth A, Gauvreau K, Powell A, Landzberg M, Lock
J, Walsh E, Geva T, Right Ventricular Size and Function and Age at Repair
Predict Major Adverse Outcomes Late after Tetralogy of Fallot Repair,
Heart 2006; E pub 29 Nov 2006.
- Knauth AL, McElhinney DB, Shinnar M, Leigh JS, A
Method of Vascular Impedance Spectrum Analysis for Identifying the Location
and Magnitude of Wave Reflections in the Aorta, Cardiovascular Engineering
2004; 4(4):261-272.
- Knauth AL, Lock JE, Perry SB, McElhinney DB, Gauvreau
K, Landzberg MJ, Rome JJ, Hellenbrand WE, Ruiz CE, Jenkins KJ, Transcatheter
device closure of congenital and postoperative residual ventricular
septal defects, Circulation 2004; 110(5):501-7.
- Hoydu AK, Kitano Y, Kriss A, Hensley H, Bergey P,
Flake A, Hubbard A, Leigh JS Jr, In vivo, in utero microscopic magnetic
resonance imaging: application in a rat model of diaphragmatic hernia.
Magnetic Resonance in Medicine 2000; 44(2):331-335.
- Fogel MA, Weinberg PM, Hoydu A, Hubbard A, Rychik
J, Jacobs M, Fellows KE, Haselgrove J, The nature of flow in the systemic
venous pathway measured by magnetic resonance blood tagging in patients
having the Fontan operation. Journal of Thoracic & Cardiovascular
Surgery 1997; 114(6):1032-41.
- Fogel MA, Weinberg PM, Hoydu AK, Hubbard AM, Rychik
J, Jacobs ML, Fellows KE, Haselgrove J, Effect of surgical reconstruction
on flow profiles in the aorta using magnetic resonance blood tagging.
Annals of Thoracic Surgery 1997; 63(6):1691-1700.
- Hoydu AK, Bergey PD, Haselgrove JC, A MRI bolus tagging
method for observing helical flow in the descending aorta. Magnetic
Resonance in Medicine 1994; 32(6)794-800.
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